Activated via the antibiotic rifampicin and several plant metabolites, for instance hyperforin, guggulipid, colupulone, and isoflavones. Reaction to unique ligands is species-precise. Activated by In a natural way occurring steroids, like pregnenolone and progesterone. Binds to some reaction aspect within the promoters of your CYP3A4 and ABCB1/MDR1